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A Cotyledon-based Virus-Induced Gene Silencing (Cotyledon-VIGS) approach to study specialized metabolism in medicinal plants

Liu, Y., Lyu, R., Singleton, J. J., Patra, B., Pattanaik, S. & Yuan, L., Feb 12 2024, In: Plant Methods. 20, 1, p. 26

Research output: Contribution to journal › Article › peer-review

Mitogen-activated protein kinase-mediated regulation of plant specialized metabolism

Zhou, Y., Singh, S. K., Patra, B., Liu, Y., Pattanaik, S. & Yuan, L., Jan 10 2025, In: Journal of Experimental Botany. 76, 2, p. 262-276 15 p.

Research output: Contribution to journal › Review article › peer-review

Histone deacetylases repress the accumulation of licochalcone A by inhibiting the expression of flavonoid biosynthetic pathway-related genes in licorice (Glycyrrhiza inflata)

Zeng, J., Ma, X., Li, Y., Zhou, L., Fu, J., Wang, H., Liu, Y., Yuan, L., Wang, Y. & Li, Y., Dec 2025, In: Molecular Horticulture. 5, 1, 32.

Research output: Contribution to journal › Article › peer-review

PGA37 Overexpression Promotes Chloroplast Development in Arabidopsis Roots Through Direct Transcriptional Activation of GLK2, ARR13, and ARR21

Wei, Y., Yang, H., Wang, Y., Shen, H., Zhang, S., Yang, Z., Yuan, L. & Wang, X., May 2025, In: Plants. 14, 9, 1270.

Research output: Contribution to journal › Article › peer-review

Exploring plant responses to altered gravity for advancing space agriculture

Nie, H., Zhou, W., Zheng, Z., Deng, Y., Zhang, W., Zhang, M., Jiang, Z., Zheng, H., Yuan, L., Yang, J. & Wang, H., Jun 9 2025, In: Plant Communications. 6, 6, 101370.

Research output: Contribution to journal › Review article › peer-review

Mitogen-activated protein kinase-mediated regulation of plant specialized metabolism

Zhou, Y., Singh, S. K., Patra, B., Liu, Y., Pattanaik, S. & Yuan, L., Jan 10 2025, In: Journal of Experimental Botany. 76, 2, p. 262-276 15 p.

Research output: Contribution to journal › Review article › peer-review

Transcriptome analysis and functional identification of transfer RNA-derived fragments in grape leaves exposed to UV-C radiation

Li, Y., Kong, L., Mu, H., Wang, J., Li, F., Kuang, Y., Duan, W., Fan, P., Yuan, L., Liang, Z. & Wang, L., Feb 2025, In: Plant Physiology and Biochemistry. 219, 109425.

Research output: Contribution to journal › Article › peer-review

An overview of the regulation of specialized metabolism in tobacco

Wu, X., Singh, S. K., Patra, B., Wang, J., Pattanaik, S. & Yuan, L., Mar 2025, In: Current Plant Biology. 41, 100431.

Research output: Contribution to journal › Review article › peer-review

Phase separation of MYB73 regulates seed oil biosynthesis in Arabidopsis

Yang, Y., Kong, Q., Ma, Z., Lim, P. K., Singh, S. K., Pattanaik, S., Mutwil, M., Miao, Y., Yuan, L. & Ma, W., Feb 2025, In: Plant Physiology. 197, 2, kiae674.

Research output: Contribution to journal › Article › peer-review

ZINC FINGER PROTEIN2 suppresses funiculus lignification to ensure seed loading efficiency in Arabidopsis

Low, P. M., Kong, Q., Blaschek, L., Ma, Z., Lim, P. K., Yang, Y., Quek, T., Lim, C. J. R., Singh, S. K., Crocoll, C., Engquist, E., Thorsen, J. S., Pattanaik, S., Tee, W. T., Mutwil, M., Miao, Y., Yuan, L., Xu, D., Persson, S. & Ma, W., Jun 23 2025, In: Developmental Cell. 60, 12, p. 1719-1729.e6

Research output: Contribution to journal › Article › peer-review

Transcriptional Reprogramming Deploys a Compartmentalized ‘Timebomb’ in Catharanthus roseus to Fend Off Chewing Herbivores

Liu, Y., Shi, J., Patra, B., Singh, S. K., Wu, X., Lyu, R., Liu, X., Li, Y., Wang, Y., Zhou, X., Pattanaik, S. & Yuan, L., May 2025, In: Plant, Cell and Environment. 48, 5, p. 3236-3256 21 p.

Research output: Contribution to journal › Article › peer-review

Characterization and Molecular Engineering of a N-Methyltransferase from Edible Nelumbo nucifera Leaves Involved in Nuciferine Biosynthesis

Chen, S., Wang, Z., Dong, G. Q., Zhao, H., Zhu, Y., Liu, Y., Yuan, L., Jiang, J., Liu, X. J., Liu, A. & Yu, Y., 2024, (Accepted/In press) In: Journal of Agricultural and Food Chemistry.

Research output: Contribution to journal › Article › peer-review

The evolutionary advantage of artemisinin production by Artemisia annua

Yin, Q., Xiang, L., Han, X., Zhang, Y., Lyu, R., Yuan, L. & Chen, S., Feb 2025, In: Trends in Plant Science. 30, 2, p. 213-226 14 p.

Research output: Contribution to journal › Review article › peer-review

Harnessing the spatial and transcriptional regulation of monoterpenoid indole alkaloid metabolism in Alstonia scholaris leads to the identification of broad geissoschizine cyclase activities

Méteignier, L. V., Szwarc, S., Barunava, P., Durand, M., Zamar, D. L., Birer Williams, C., Gautron, N., Dutilleul, C., Koudounas, K., Lezin, E., Perrot, T., Oudin, A., Pateyron, S., Delannoy, E., Brunaud, V., Lanoue, A., Abbasi, B. H., St-Pierre, B., Jensen, M. K. & Papon, N. & 6 others, Sun, C., Le Pogam, P., Yuan, L., Beniddir, M. A., Besseau, S. & Courdavault, V., Feb 2025, In: Plant Physiology and Biochemistry. 219, 109363.

Research output: Contribution to journal › Article › peer-review

A cytosine analogue 5-azacitidine improves the accumulation of licochalcone A in licorice Glycyrrhiza inflata

Ma, X., Jiang, N., Fu, J., Li, Y., Zhou, L., Yuan, L., Wang, Y. & Li, Y., Jan 2024, In: Journal of Plant Physiology. 292, 154145.

Research output: Contribution to journal › Article › peer-review

Integrated metabolomic and transcriptomic analysis provides insights into the flavonoid formation in different Glycyrrhiza species

Li, Y., Xie, Z., Huang, Y., Zeng, J., Yang, C., Yuan, L., Wang, Y. & Li, Y., Feb 2024, In: Industrial Crops and Products. 208, 117796.

Research output: Contribution to journal › Article › peer-review

A Cotyledon-based Virus-Induced Gene Silencing (Cotyledon-VIGS) approach to study specialized metabolism in medicinal plants

Liu, Y., Lyu, R., Singleton, J. J., Patra, B., Pattanaik, S. & Yuan, L., Dec 2024, In: Plant Methods. 20, 1, 26.

Research output: Contribution to journal › Article › peer-review

Improving digestibility of sorghum proteins by CRISPR/Cas9-based genome editing

Li, X., Liu, W., Wang, G., Sun, S. S. M., Yuan, L. & Wang, J., Jan 1 2024, In: Food and Energy Security. 13, 1, e506.

Research output: Contribution to journal › Article › peer-review

VvBBX44 and VvMYBA1 form a regulatory feedback loop to balance anthocyanin biosynthesis in grape

Liu, W., Mu, H., Yuan, L., Li, Y., Li, Y., Li, S., Ren, C., Duan, W., Fan, P., Dai, Z., Zhou, Y., Liang, Z., Li, S. & Wang, L., Oct 1 2023, In: Horticulture Research. 10, 10, uhad176.

Research output: Contribution to journal › Article › peer-review

MYB30 and MYB14 form a repressor-activator module with WRKY8 that controls stilbene biosynthesis in grapevine

Mu, H., Li, Y., Yuan, L., Jiang, J., Wei, Y., Duan, W., Fan, P., Li, S., Liang, Z. & Wang, L., Jan 2023, In: Plant Cell. 35, 1, p. 552-573 22 p.

Research output: Contribution to journal › Article › peer-review

FY25 Artesunate as Treatment for Childhood Acute Myeloid Leukemia C4935

Richards, C. (PI), Badgett, J. (CoI), Hill, K. (CoI), Ji, H. (CoI) & Yuan, L. (CoI)

KY Cabinet for Health and Family Services

7/1/24 → 6/30/25

Project: Research project

Cigar Reference Products Program

Chambers, O. (PI), Fisher, A. (CoI), Fisher, C. (CoI), Ji, H. (CoI), McNees, C. (CoI), Shelton, B. (CoI) & Yuan, L. (CoI)

Food and Drug Administration

2/1/20 → 1/31/25

Project: Research project

FY24 Artesunate as Treatment for Childhood Acute Myeloid Leukemia

Kolesar, J. (PI), Badgett, J. (CoI), Hill, K. (CoI), Ji, H. (CoI) & Yuan, L. (CoI)

KY Cabinet for Health and Family Services

7/1/22 → 6/30/24

Project: Research project

Cigar Reference Products Program

Chambers, O. (PI), Fisher, A. (CoI), Fisher, C. (CoI), Ji, H. (CoI), McNees, C. (CoI), Shelton, B. (CoI) & Yuan, L. (CoI)

Food and Drug Administration

2/1/20 → 1/31/24

Project: Research project

Demeetra UKY Industrial Hemp

Yuan, L. (PI)

Demeetra Agbio Incorporated

4/1/19 → 3/31/20

Project: Research project

RJRTARUKY-4-BP&LY

Patra, B. (PI) & Yuan, L. (CoI)

RJ Reynolds Tobacco Co

12/19/18 → 1/31/23

Project: Research project

RJRTARUKY-3-SP&LY

Pattanaik, S. (PI) & Yuan, L. (CoI)

RJ Reynolds Tobacco Co

4/29/16 → 2/16/19

Project: Research project

RJRTARUKY-2-SP&LY

Pattanaik, S. (PI) & Yuan, L. (CoI)

RJ Reynolds Tobacco Co

4/29/16 → 2/16/19

Project: Research project

BAT SPTobacco1

Pattanaik, S. (PI) & Yuan, L. (CoI)

British American Tobacco

2/13/17 → 2/28/20

Project: Research project

High-throughput screening for fast neutron-induced mutations in the tobacco CBT-ol synthase gene using Illumina amplicon sequencing

Zaitlin, D. (PI), Farman, M. (CoI), Miller, R. (CoI), Wagner, G. (CoI) & Yuan, L. (CoI)

British American Tobacco

9/12/13 → 9/11/20

Project: Research project

Production of proteins in plant

Yuan, L. (PI)

Impossible Foods Incorporated

2/14/14 → 2/14/16

Project: Research project

BAT GWTobacco1

Wagner, G. (PI), Mihaylova-Kroumova, A. (CoI), Zaitlin, D. (CoI) & Yuan, L. (Former CoI)

British American Tobacco

9/12/13 → 12/31/21

Project: Research project

Production of Abietic Acid and Other Potentially-Useful, Related Diterpenes in Tobacco Trichomes

Chappell, J. (PI), Tang, G. (CoI), Wagner, G. (CoI) & Yuan, L. (CoI)

Procter & Gamble Company

4/1/08 → 12/31/11

Project: Research project

Production of Abietic Acid and Other Potentially-Useful, Related Diterpenes in Tobacco Trichomes

Wagner, G. (PI), Chappell, J. (CoI), Tang, G. (CoI) & Yuan, L. (CoI)

Procter & Gamble Company

4/1/08 → 12/31/11

Project: Research project

Novel Approach to Microbial Hydrogen Production

Yuan, L. (PI)

Farasis Energy Inc

8/1/06 → 4/30/07

Project: Research project

FY23 Artesunate as Treatment for Childhood Acute Myeloid Leukemia

Kolesar, J. (PI), Badgett, J. (CoI), Ellingson, S. (CoI), Hill, K. (CoI), Ji, H. (CoI) & Yuan, L. (CoI)

KY Cabinet for Health and Family Services

7/1/22 → 6/30/23

Project: Research project

ARS/SCA: Tall Fescue Characteristics

Yuan, L. (PI), Bush, L. (CoI) & Ji, H. (CoI)

Agricultural Research Service

8/1/14 → 4/30/18

Project: Research project

KY EPSCoR: Powering the Kentucky Bioeconomy for a Sustainable Future (Yuan Scope)

Yuan, L. (PI)

KY Council on Postsecondary Education

6/1/14 → 12/30/18

Project: Research project

Scope: Smokeless Tobacco Reference Product Development, Distribution and Research

Durbin, E. B. (PI), Chambers, O. (CoI), Fisher, A. (CoI), Ji, H. (CoI), Moe, L. (CoI), Shelton, B. (CoI), Yuan, L. (CoI) & Canete, S. (Former CoI)

Food and Drug Administration

3/1/16 → 2/29/20

Project: Research project

Scope: Smokeless Tobacco Reference Product Development, Distribution and Research

Shelton, B. (PI), Chambers, O. (CoI), Durbin, E. B. (CoI), Fisher, A. (CoI), Ji, H. (CoI), Moe, L. (CoI), Yuan, L. (CoI) & Canete, S. (Former CoI)

Food and Drug Administration

3/1/16 → 2/29/20

Project: Research project

Associated Departments

KY Tobacco Research & Dev Ctr